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People who carry these alleles are at elevated risk of venous thrombosis, simply because fibrin is definitely the dominant ingredient of thrombi during the veins. In arteries, however, platelets Engage in a far more prominent function in thrombus formation, and these SNPs have little prognostic value. Right until 1996, none of the SNPs current in genes pinpointing platelet operate had been instructed to influence the chance of arterial thrombosis.
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